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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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SARS-CoV-2 ORF8 accessory protein is a virulence factor

M Bello-Perez1, J Hurtado-Tamayo1, A Z Mykytyn2

  • 1Department of Molecular and Cell Biology, National Center for Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid , Madrid, Spain.

Mbio
|August 25, 2023
PubMed
Summary

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF8 protein contributes to COVID-19 virulence by promoting inflammation and activating macrophages. Targeting ORF8 may offer new therapeutic strategies for COVID-19.

Keywords:
SARS-CoV-2accessory proteinscoronavirusviral pathogenesisvirulence

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