Prospective of Pancreatic Cancer Diagnosis Using Cardiac Sensing

Area of Science:

• Oncology and Cardiology
• Biomolecular mechanisms
• Diagnostic imaging

Background:

• Pancreatic carcinoma (Ca Pancreas) is a significant cause of cancer mortality globally.
• Early, non-invasive diagnosis of Ca Pancreas remains challenging due to delayed symptom presentation.
• Existing diagnostic methods include endoscopic ultrasound with biopsy (gold standard), CT, MRI, and emerging techniques like AI and radiomics.

Purpose of the Study:

• To review the correlation between pancreatic cancer and cardiovascular system.
• To explore how pancreatic tumors affect the heart physiologically and molecularly.
• To identify potential biomarkers for early Ca Pancreas detection through cardiac associations.

Main Methods:

• Literature review of studies investigating the pancreatic cancer-heart relationship.
• Analysis of molecular and physiological mechanisms linking Ca Pancreas to cardiac dysfunction.
• Identification of key genetic (SMAD4) and molecular (IGF, MAPK, ApoE) factors and biomarkers (CA19-9).

Main Results:

• Pancreatic cancer impacts the heart at physiological and molecular levels.
• Specific molecular disruptions (SMAD4, IGF, MAPK, ApoE) and elevated CA19-9 markers are associated with cardiac effects.
• A correlation between pancreatic cancer and cardiovascular system alterations is established.

Conclusions:

• The interplay between pancreatic cancer and the heart is complex, involving molecular and physiological changes.
• Understanding this correlation may offer novel avenues for early non-invasive diagnosis of pancreatic cancer.
• Further research is needed to solidify the link and develop diagnostic strategies based on cardiac markers.