Decreased 25-Hydroxy Vitamin D Level Is Associated with All-Cause Mortality in Patients with Type 2 Diabetes at High
Alena Stančáková Yaluri1, Ivan Tkáč1, Katarína Tokarčíková1
1Department of Internal Medicine 4, Faculty of Medicine, P. J. Šafárik University and L. Pasteur University Hospital, 04190 Košice, Slovakia.
Metabolites
|August 25, 2023
Summary
Vitamin D deficiency is strongly linked to cardiovascular events and mortality in type 2 diabetes patients. Low levels of 25-hydroxy-vitamin D (25(OH)D) were the most significant predictor in this high-risk group.
Area of Science:
- Endocrinology
- Cardiology
- Nutritional Science
Background:
- Cardiovascular diseases (CVD) are a major cause of death in type 2 diabetes (T2D).
- Improved prediction of CVD events and mortality requires novel biomarkers.
- Atherosclerosis-related biomarkers' role in T2D cardiovascular risk needs further investigation.
Purpose of the Study:
- To investigate the association of specific atherosclerosis-related biomarkers with cardiovascular events and all-cause mortality.
- To identify the most significant predictor among osteoprotegerin (OPG), 25-hydroxy-vitamin D (25(OH)D), C-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), and asymmetric dimethylarginine (ADMA).
Main Methods:
- Prospective study of 190 patients with type 2 diabetes.
- 5.6-year follow-up for cardiovascular events and all-cause mortality.
- Logistic regression analysis adjusted for baseline cardiovascular status and risk factors.
Main Results:
- The primary outcome occurred in 46.8% of participants.
- Individually, 25(OH)D, CRP, and LBP predicted the primary outcome.
- In a multivariable model including all biomarkers, only decreased 25(OH)D remained a significant predictor.
- Reduced 25(OH)D levels were associated with a two-fold increase in all-cause mortality.
Conclusions:
- Vitamin D deficiency is the strongest predictor of cardiovascular events and all-cause mortality in high-risk type 2 diabetes patients.
- 25-hydroxy-vitamin D (25(OH)D) serves as a crucial prognostic biomarker in this population.
- Targeting vitamin D deficiency may be a potential strategy to reduce cardiovascular risk in type 2 diabetes.
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