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Updated: Jul 18, 2025
08:24
Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins
Published on: November 18, 2016
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Survey of Bacterial Isolates and Their Antimicrobial Susceptibility Patterns from Dogs with Infective Endocarditis
Alexander Schreiber1, Steven E Epstein2, Barbara A Byrne3
1VCA Animal Specialty Emergency Center, 1535 S Sepulveda Blvd, Los Angeles, CA 90025, USA.
Pathogens (Basel, Switzerland)
|August 25, 2023
Summary
Bacterial isolates from dogs with infective endocarditis (IE) commonly show multidrug resistance (MDR). Previous fluoroquinolone use in dogs with IE was linked to higher resistance rates, highlighting the need for targeted antimicrobial susceptibility testing.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Microbiology
Background:
- Infective endocarditis (IE) is a severe, life-threatening condition in dogs.
- Characterization of bacterial agents and their antimicrobial resistance patterns in canine IE is limited.
Purpose of the Study:
- To identify bacterial isolates from dogs diagnosed with IE.
- To determine antimicrobial susceptibility patterns of these isolates.
- To assess the association between antimicrobial resistance and survival or prior antimicrobial exposure.
Main Methods:
- Retrospective analysis of canine IE cases and bacterial isolates.
- Antimicrobial susceptibility testing using current veterinary cutoffs.
- Statistical analysis to correlate resistance with clinical outcomes and treatment history.
Main Results:
- Fifty-one isolates were identified from 45 dogs; Staphylococcus spp. was most common (27.5%).
- Thirty-six percent of isolates exhibited multidrug resistance (MDR).
- Prior fluoroquinolone exposure was associated with increased non-intrinsic fluoroquinolone resistance (62.5% vs. 9.5%).
Conclusions:
- Antimicrobial resistance and MDR are prevalent in canine IE.
- Resistance patterns were not linked to survival rates in this cohort.
- Antimicrobial susceptibility testing is crucial for guiding effective treatment in dogs with IE.
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