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Updated: Jul 18, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

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Gut Microbiota Interventions to Retain Residual Kidney Function.

Denise Mafra^1,2, Julie A Kemp¹, Natalia A Borges³

¹Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niteroi 24020-140, Brazil.

|August 25, 2023

Summary

Preserving residual kidney function in chronic kidney disease (CKD) is crucial. Modulating gut microbiota through diet and other strategies may help mitigate kidney damage and improve patient outcomes.

Keywords:

chronic kidney disease gut microbiota interventions nutrition residual kidney function

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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Area of Science:

Nephrology
Microbiology
Gastroenterology

Background:

Residual kidney function is vital for chronic kidney disease (CKD) patients' quality of life and prognosis.
Gut dysbiosis, uremic toxins, and endotoxemia contribute to kidney damage in CKD.
Diet is a primary driver of gut dysbiosis, influencing CKD progression.

Purpose of the Study:

To review the role of gut microbiota metabolism in residual kidney function (RKF) in CKD.
To explore strategies for preserving RKF by modulating gut microbiota balance.

Main Methods:

Literature review of studies on gut microbiota, CKD, and RKF.
Analysis of dietary, medicinal, and fecal transplantation interventions for gut microbiota modulation.

Main Results:

Gut microbiota composition significantly impacts CKD progression and RKF.
Dietary interventions show promise in modulating gut microbiota and potentially preserving RKF.
Further research is needed to fully elucidate the effects of microbiota modulation on RKF.

Conclusions:

Modulating gut microbiota is a promising strategy to preserve residual kidney function in CKD patients.
Dietary interventions represent a key avenue for managing gut dysbiosis and its renal consequences.
Targeting the gut-kidney axis offers potential therapeutic benefits for CKD management.