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Perspectives and mechanisms for targeting mitotic catastrophe in cancer treatment

Zhaoshi Bai1, Yiran Zhou2, Yaling Peng3

  • 1Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|August 25, 2023
PubMed

Insights

Mitotic catastrophe, a cell death mode with unique nuclear changes, is key in cancer therapy. Understanding and inducing it can overcome apoptosis resistance and enhance cancer immunotherapy.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Therapeutics

Background:

  • Mitotic catastrophe is a distinct cell death pathway characterized by nuclear abnormalities like multi- and micronucleation.
  • It is a frequent outcome of cancer treatments, yet a complete understanding is missing.
  • Existing knowledge gaps hinder its full therapeutic potential.

Purpose of the Study:

  • To review anticancer drugs that induce mitotic catastrophe.
  • To evaluate the role, advantages, and disadvantages of mitotic catastrophe in cancer treatment.
  • To explore strategies for optimizing its therapeutic use and its impact on cancer immunotherapy.

Main Methods:

  • Literature review of anticancer drugs targeting mitosis.
  • Analysis of mitotic catastrophe's interplay with other cell death mechanisms.
  • Evaluation of current and potential therapeutic strategies involving mitotic catastrophe.

Main Results:

  • Identified classes of drugs inducing mitotic catastrophe: microtubule agents, SAC kinase inhibitors, DNA damage agents, and DDR inhibitors.
  • Assessed the dual role of mitotic catastrophe in cancer treatment, noting both benefits and drawbacks.
  • Explored the regulatory function of mitotic catastrophe in cancer immunotherapy.

Conclusions:

  • Mitotic catastrophe induction is a promising strategy to overcome apoptosis resistance in cancer.
  • Harnessing mitotic catastrophe can significantly enhance the efficacy of cancer immunotherapy.
  • Further research into optimizing mitotic catastrophe induction is warranted for improved cancer treatment outcomes.
Keywords:
Apoptosis resistanceCancer immunotherapyCell death modesMitotic catastropheMulti and/or micronucleation

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