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Advances in long non-coding RNA regulating drug resistance of cancer

Zhang Ying1, Sun Wenjing1, Bai Jing1

  • 1Key laboratory of preservation of human genetic resources and disease control in China, Harbin Medical University, Ministry of Education, Harbin 150081, China; Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.

Gene
|August 25, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators of cancer drug resistance. Understanding lncRNA mechanisms, especially exosomal lncRNAs, offers new therapeutic strategies for overcoming treatment challenges.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Drug resistance presents a significant challenge in cancer therapy.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cancer progression and treatment response.

Purpose of the Study:

  • To review recent advancements in understanding how lncRNAs regulate drug resistance in cancer.
  • To highlight the specific role and mechanisms of exosomal lncRNAs in mediating cancer drug resistance.

Main Methods:

  • Literature review of studies on lncRNAs and cancer drug resistance.
  • Focus on mechanisms including ATP binding transporter overexpression, DNA damage response, apoptosis, epithelial-mesenchymal transition, and cancer stem cell formation.
  • Emphasis on emerging research concerning exosomal lncRNAs.

Main Results:

  • lncRNAs influence cancer drug resistance through diverse cellular processes.
  • Exosomal lncRNAs represent a novel and developing area of research in cancer drug resistance.
  • Specific mechanisms of lncRNA action include modulation of key pathways involved in treatment failure.

Conclusions:

  • Further investigation into lncRNA functions and mechanisms is crucial for improving cancer treatment outcomes.
  • Targeting lncRNAs, particularly exosomal lncRNAs, holds potential for developing innovative therapeutic strategies against drug-resistant cancers.
Keywords:
ApoptosisCancerDrug resistanceExosomesLong non-coding RNA

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