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Assessing cancer in people with profound and multiple disabilities
Daniel Satgé1,2, Motoi Nishi3, Brigitte Trétarre4,5,6
1Oncodéfi, 209 Avenue des Apothicaires, Parc Euromédecine, Montpellier, 34090, France. daniel.satge@oncodefi.org.
BMC Cancer
|August 25, 2023
Summary
Individuals with profound and multiple disabilities (PMD) have a unique cancer risk profile, with digestive tract cancers occurring earlier. Early detection and monitoring are crucial for this population.
Area of Science:
- Oncology
- Disability Studies
- Epidemiology
Background:
- Cancer surveillance is challenging for individuals with profound and multiple disabilities (PMD) due to unknown cancer frequency and distribution.
- While overall cancer risk may be lower in PMD, specific risk factors and protective elements differ from the general population (GP).
Purpose of the Study:
- To investigate the frequency, distribution, and risk factors of cancer in individuals with profound and multiple disabilities (PMD).
- To inform appropriate cancer surveillance strategies for the PMD subgroup.
Main Methods:
- Systematic and synthetic review of existing medical literature.
- Focused search including Japanese data.
Main Results:
- Individuals with PMD may have a lower overall cancer risk, potentially due to shorter life expectancy and reduced exposure to common risk factors.
- PMD individuals exhibit increased frequency of conditions like GERD and chronic cystitis, elevating risks for specific cancers (esophagus, stomach, bladder, testes).
- A distinct tumor profile was observed in PMD, with frequent digestive tract cancers diagnosed significantly earlier than in the GP.
Conclusions:
- Appropriate cancer monitoring for individuals with PMD is essential, including screenings for breast and colon cancer.
- Regular monitoring of the esophagus, stomach, urinary bladder, and testicles is recommended for the PMD population.
- Population-based epidemiological studies are needed to refine understanding of cancer risks and distribution in PMD.
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