Related Experiment Video
Updated: Jul 18, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
COVID-19 and Neurological Manifestations.
Kathleen Forero1, Raghad Buqaileh1, Clare Sunderman1
1Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA.
This review covers coronavirus disease 2019 (COVID-19) symptoms, focusing on neurological effects. It explores how SARS-CoV-2 infects the body via ACE2 receptors, impacting multiple organs.
Area of Science:
- Virology
- Neurology
- Public Health
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a global pandemic via airborne transmission.
- The virus binds to angiotensin converting enzyme 2 (ACE2) receptors, which are present in organs like the lungs, heart, gastrointestinal tract, and brain.
Purpose of the Study:
- To review current knowledge on COVID-19 symptoms.
- To highlight neurological symptoms associated with COVID-19.
- To discuss potential mechanisms of SARS-CoV-2 infection in the human body.
Main Methods:
- Literature review of existing studies on SARS-CoV-2.
- Analysis of reported COVID-19 symptoms, with a focus on neurological manifestations.
- Examination of the role of ACE2 receptors in viral pathogenesis.
Main Results:
- COVID-19 presents with a range of symptoms, including significant neurological effects.
- ACE2 receptors are crucial for SARS-CoV-2 entry into various cell types.
- The virus can affect multiple organ systems beyond the respiratory tract.
Conclusions:
- Understanding the diverse symptoms of COVID-19, especially neurological ones, is critical for patient management.
- The interaction between SARS-CoV-2 and ACE2 receptors provides insight into the virus's widespread impact.
- Further research is needed to fully elucidate the mechanisms of SARS-CoV-2 infection and its long-term consequences.
Related Concept Videos
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Chronic Kidney Disease II: Clinical Manifestations
Neural Regulation
Parkinson's Disease: Overview
Coronary Artery Disease III: Clinical Manifestations
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

