Related Experiment Videos
The pathogenicities of Cylindrocarpon tonkinense and Fusarium solani in the rabbit cornea
Abstract:
The pathogenicity of Cylindrocarpon tonkinense in the cornea was evaluated and compared with that of Fusarium solani in rabbits. F. solani was inoculated into the right eyes of 14 rabbits and C. tonkinense was into the left eyes of same rabbits. The corneal lesions of both eyes were examined carefully by slit lamp every day for three weeks and the severity of infections were compared each other. For histopathologic study, several eyes were enucleated periodically. C. tonkinense has a pathogenicity equally strong as F. solani in this inoculum size (10(4) microconidia per cornea) and produced severe infection in rabbit eyes.
Insights
Cylindrocarpon tonkinense and Fusarium solani cause equally severe corneal infections in rabbits. This study highlights C. tonkinense as a significant ocular pathogen.
Area of Science:
- Ophthalmology
- Mycology
- Veterinary Medicine
Background:
- Fungal keratitis is a serious eye infection.
- Fusarium solani is a known cause of fungal keratitis.
- The pathogenicity of Cylindrocarpon tonkinense in the cornea is less understood.
Purpose of the Study:
- To evaluate and compare the pathogenicity of Cylindrocarpon tonkinense with Fusarium solani in rabbit corneas.
Main Methods:
- Rabbits were inoculated with F. solani in one eye and C. tonkinense in the other.
- Corneal lesions were monitored daily using slit-lamp examination for three weeks.
- Histopathological analysis was performed on enucleated eyes.
Main Results:
- C. tonkinense demonstrated pathogenicity comparable to F. solani.
- Both fungi produced severe infections in rabbit eyes at an inoculum size of 10(4) microconidia per cornea.
Conclusions:
- Cylindrocarpon tonkinense is an equally potent ocular pathogen as Fusarium solani.
- C. tonkinense should be considered in the differential diagnosis of fungal keratitis.