Related Experiment Video

Updated: Jul 18, 2025

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
06:49

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Published on: May 31, 2017

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COVID-19-Related Myocarditis: Are We There Yet? A Case Report of COVID-19-Related Fulminant Myocarditis

Alessandro Pierri1,2, Giulia Gagno1,2, Alessandra Fluca1,2

  • 1Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34139 Trieste, Italy.

Biomedicines
|August 26, 2023
PubMed

Insights

Sudden cardiac death in a young woman was linked to fulminant myocarditis following a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This case highlights the potential for direct cardiac involvement and severe outcomes from COVID-19.

Area of Science:

  • Cardiology
  • Virology
  • Pathology

Background:

  • COVID-19, caused by SARS-CoV-2, presents diverse cardiovascular complications.
  • Acute myocarditis is a rare but severe manifestation of SARS-CoV-2 infection.
  • Histological confirmation of cardiac injury in SARS-CoV-2 myocarditis is often lacking in reported cases.

Observation:

  • A young woman experienced sudden death shortly after testing positive for SARS-CoV-2.
  • Autopsy revealed microscopic and genetic evidence suggestive of direct cardiac involvement.

Findings:

  • The findings are consistent with a diagnosis of fulminant myocarditis.
  • This suggests a direct pathogenic role of SARS-CoV-2 in causing severe myocardial inflammation.

Implications:

  • This case underscores the critical need for considering myocarditis in sudden deaths post-COVID-19.
  • Further research is warranted to understand the mechanisms and long-term cardiac sequelae of SARS-CoV-2 infection.
  • Early recognition and management of cardiac complications in COVID-19 patients are crucial.

Keywords:
COVID-19myocarditispost-mortem examinationsudden death

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