Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

629
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
629
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

194
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
194
Liver Physiology01:30

Liver Physiology

632
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
632
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
Liver Histology01:27

Liver Histology

886
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
886
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

112
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
112

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Value of Exercise Testing in Patients with Liver Cirrhosis.

Diagnostics (Basel, Switzerland)·2026
Same author

Safety, pharmacokinetics, and preliminary efficacy of VS-01, an intraperitoneal liposomal infusion, in patients with decompensated liver cirrhosis, ascites, and covert hepatic encephalopathy: a phase 1b, first-in-human, open-label, non-randomised, single ascending and multiple dose study.

The lancet. Gastroenterology & hepatology·2026
Same author

Progression of liver fibrosis after metabolic bariatric surgery in a MASLD rat model.

Clinical nutrition (Edinburgh, Scotland)·2025
Same author

Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis.

Antioxidants (Basel, Switzerland)·2025
Same author

MASLD is related to impaired alcohol dehydrogenase (ADH) activity and elevated blood ethanol levels: Role of TNFα and JNK.

Redox biology·2024
Same author

Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease.

Nutrients·2024

Related Experiment Video

Updated: Jul 18, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

955

Steatotic Liver Disease: Metabolic Dysfunction, Alcohol, or Both?

Katharina Staufer1, Rudolf E Stauber2

  • 1Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.

Biomedicines
|August 26, 2023
PubMed
Summary

Steatotic liver disease (SLD), encompassing metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-related liver disease (ALD), presents diagnostic challenges due to overlapping symptoms. Understanding their commonalities is crucial for improved clinical care and research.

Keywords:
alcohol-related liver disease (ALD)metabolic dysfunction-associated steatohepatitis (MASH)metabolic-dysfunction associated steatotic liver disease (MASLD)non-alcoholic fatty liver disease (NAFLD)steatotic liver disease (SLD)

More Related Videos

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

6.4K
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

14.4K

Related Experiment Videos

Last Updated: Jul 18, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

955
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

6.4K
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

14.4K

Area of Science:

  • Hepatology
  • Gastroenterology
  • Public Health

Background:

  • Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are leading causes of chronic liver disease globally.
  • Both conditions, now under the umbrella term steatotic liver disease (SLD), share clinical similarities but differ in prognosis and treatment.
  • NAFLD is rapidly increasing, while ALD prevalence remains stable, complicating early diagnosis.

Purpose of the Study:

  • To review current knowledge on the commonalities between NAFLD/MASLD and ALD.
  • To identify clinical and research gaps in understanding steatotic liver disease (SLD).
  • To emphasize the need for improved diagnostic strategies for SLD.

Main Methods:

  • Literature review of existing studies on NAFLD, ALD, and SLD.
  • Analysis of clinical presentations, prognoses, and treatment approaches.
  • Synthesis of information on shared characteristics and differences.

Main Results:

  • NAFLD/MASLD and ALD exhibit overlapping clinical features, making differentiation difficult.
  • The introduction of SLD aims to reduce stigma associated with fatty liver disease.
  • Metabolic dysfunction-associated steatotic liver disease (MASLD) and ALD exist on a spectrum, including MetALD.

Conclusions:

  • Accurate and early diagnosis of SLD is essential but challenging.
  • Further research is needed to elucidate the common denominators and distinct aspects of MASLD and ALD.
  • A unified understanding of SLD is critical for advancing patient care and public health strategies.