Related Experiment Video

Updated: Jul 18, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

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Coming of Age: Targeting Cyclin K in Cancers

Yi Xiao1, Jixin Dong1

  • 1Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Cells
|August 26, 2023
PubMed

Insights

Cyclin K is a key regulator in cancer cell growth and therapeutic resistance, offering new drug targets. This review explores Cyclin K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cyclins and cyclin-dependent kinases (CDKs) are crucial in cancer development.
  • Several CDK4/6 inhibitors are FDA-approved, highlighting CDK pathway importance in cancer therapy.
  • Cyclin K's role in cancer remains less understood but shows therapeutic promise.

Purpose of the Study:

  • To review the role and therapeutic potential of Cyclin K in various cancers.
  • To detail the discovery, targets, and functions of Cyclin K-CDK12/13 complexes.
  • To summarize current Cyclin K-targeting strategies and identify knowledge gaps.

Main Methods:

  • Literature review of studies on Cyclin K in cancer.
  • Analysis of Cyclin K's regulation of biological processes (DNA damage response, mitosis).
  • Examination of Cyclin K-CDK12/13 complex functions and phosphorylation targets.

Main Results:

  • Cyclin K regulates critical cellular processes including DNA damage response and mitosis.
  • Cyclin K is implicated in cancer cell proliferation and resistance to therapy.
  • Emerging evidence supports Cyclin K's druggability for cancer treatment.

Conclusions:

  • Cyclin K presents a promising therapeutic target for novel cancer treatments.
  • Further research into Cyclin K's mechanisms and drug development is warranted.
  • Targeting Cyclin K could overcome therapeutic resistance in cancer.
Keywords:
CDKCyclin Kcancercyclindegraderinhibitorphosphorylation

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