Related Experiment Video
Updated: Jul 18, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
The Long Non-Coding RNA ANRIL in Cancers
Aymeric Sanchez1, Julien Lhuillier1, Guillaume Grosjean2
1CNRS, Université de Lorraine, IMoPA, F-54000 Nancy, France.
Abstract:
ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome 9p21 region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes, including cell cycle control and proliferation. Dysregulation of ANRIL has been associated with several diseases like cancers and cardiovascular diseases, for instance. Understanding the oncogenic role of ANRIL and its potential as a diagnostic and prognostic biomarker in cancer is crucial. This review provides insights into the regulatory mechanisms and oncogenic significance of the 9p21 locus and ANRIL in cancer.
Related Concept Videos
lncRNA - Long Non-coding RNAs
MicroRNAs
Experimental RNAi
Types of RNA
RNA Performs Diverse...
RNA Splicing
RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

