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Methods for Radiolabeling Nanoparticles (Part 3): Therapeutic Use.

Valeria Bentivoglio1, Pallavi Nayak1, Michela Varani1

  • 1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.

Biomolecules
|August 26, 2023
PubMed
Summary

Researchers reviewed methods for radiolabeling nanoparticles with therapeutic isotopes. Direct encapsulation is the most reliable method, showing promise for cancer treatment, but more clinical studies are needed.

Keywords:
cancer therapynanoparticlesnanotechnologynuclear medicineradiolabeling

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Area of Science:

  • Nanomedicine
  • Radiochemistry
  • Oncology

Background:

  • Systematic reviews have explored the diagnostic applications of nanoparticles (NPs).
  • This study focuses on the therapeutic radiolabeling of NPs using various isotopes.

Purpose of the Study:

  • To review and analyze published methods for radiolabeling nanoparticles with therapeutic isotopes (alpha, beta, Auger's electron emitters).
  • To identify common nanoparticle types, isotopes, and labeling techniques in published literature.

Main Methods:

  • Systematic review of 234 papers on radiolabeled nanoparticles.
  • Analysis of nanoparticle types, isotopes used, and labeling methodologies.

Main Results:

  • Poly(lactic-co-glycolic acid) (PLGA) and polyamidoamine (PAMAM) nanoparticles are most common.
  • Lutetium-177 (177Lu) is the most frequently used therapeutic isotope.
  • Direct isotope encapsulation is the most reliable and reproducible radiolabeling method.

Conclusions:

  • Radiolabeled nanoparticles demonstrate potential in treating metastatic breast and lung cancer.
  • Further clinical research is essential, particularly comparing nanoparticle efficacy against traditional chemotherapy.