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Updated: Jul 18, 2025
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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?
Mirjam Brackhan1,2, Marina Arribas-Blazquez3,4, Isabel Lastres-Becker2,5,6,7
1Instituto de Investigación Sanitaria La Paz (IdiPaz), 28029 Madrid, Spain.
Antioxidants (Basel, Switzerland)
|August 26, 2023
Summary
Aging accelerates neurodegeneration by impacting cellular mechanisms. This review explores how the nuclear factor erythroid-2-related factor 2 (NRF2) pathway interacts with aging and TAU protein, suggesting NRF2 as a therapeutic target for tauopathies.
Area of Science:
- Neuroscience
- Cellular Biology
- Aging Research
Background:
- Aging is a primary risk factor for neurodegenerative diseases.
- Cellular aging mechanisms contribute to neurodegeneration.
- The role of nuclear factor erythroid-2-related factor 2 (NRF2) in aging and neurodegeneration requires further elucidation.
Purpose of the Study:
- To review the relationship between aging-associated cellular mechanisms, NRF2, and TAU protein.
- To investigate NRF2's role in key neurodegenerative processes linked to aging.
- To analyze the impact of aging on TAU protein aggregation and spread.
Main Methods:
- Literature review focusing on cellular mechanisms of aging.
- Analysis of NRF2 signaling in relation to genomic instability, protein degradation, senescence, and inflammation.
- Examination of aging effects on TAU protein levels, aggregation, and spread.
- Investigation of the NRF2-TAU interconnection in tauopathies.
Main Results:
- Aging impacts cellular processes like genomic stability, proteasomal/autophagy function, senescence, and inflammation.
- Aging affects TAU protein levels, aggregation, and propagation.
- Alterations in the NRF2 pathway are relevant in both primary and secondary tauopathies.
Conclusions:
- NRF2 plays a significant role in cellular mechanisms affected by aging.
- The NRF2 signaling pathway is interconnected with TAU pathology in neurodegeneration.
- NRF2 represents a potential therapeutic target for tauopathies.
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