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Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
Published on: May 24, 2024
Novel Therapeutic Approaches to Liver Fibrosis Based on Targeting Oxidative Stress
Ana Blas-García1,2,3, Nadezda Apostolova2,3,4
1Departamento de Fisiología, Universitat de València, Av. Blasco Ibáñez, 15, 46010 Valencia, Spain.
Abstract:
Chronic liver disease (CLD) constitutes a growing global health issue, with no effective treatments currently available. Oxidative stress closely interacts with other cellular and molecular processes to trigger stress pathways in different hepatic cells and fuel the development of liver fibrosis. Therefore, inhibition of reactive oxygen species (ROS)-mediated effects and modulation of major antioxidant responses to counteract oxidative stress-induced damage have emerged as interesting targets to prevent or ameliorate liver injury. Although many preclinical studies have shown that dietary supplements with antioxidant properties can significantly prevent CLD progression in animal models, this strategy has not proved effective to significantly reduce fibrosis when translated into clinical trials. Novel and more specific therapeutic approaches are thus required to alleviate oxidative stress and reduce liver fibrosis. We have reviewed the relevant literature concerning the crucial role of alterations in redox homeostasis in different hepatic cell types during the progression of CLD and discussed current pharmacological approaches to ameliorate fibrosis by reducing oxidative stress focusing on selective modulation of enzymatic oxidant sources, antioxidant systems and ROS-mediated pathogenic processes.
Insights
Chronic liver disease (CLD) is a growing problem with no effective treatments. New therapies targeting oxidative stress and reactive oxygen species (ROS) are needed to reduce liver fibrosis.
Area of Science:
- Hepatology
- Oxidative Stress Research
- Fibrosis Pathogenesis
Background:
- Chronic liver disease (CLD) is a significant global health concern with limited treatment options.
- Oxidative stress and reactive oxygen species (ROS) play a critical role in hepatic cell damage and the development of liver fibrosis.
- Current antioxidant supplement strategies have shown limited success in clinical trials for reducing liver fibrosis.
Purpose of the Study:
- To review the literature on the role of redox homeostasis alterations in CLD progression.
- To discuss current pharmacological strategies for ameliorating liver fibrosis by targeting oxidative stress.
- To explore novel approaches for selective modulation of oxidant sources and antioxidant systems.
Main Methods:
- Literature review of studies on CLD, oxidative stress, and liver fibrosis.
- Analysis of the role of redox imbalance in various hepatic cell types.
- Discussion of pharmacological interventions targeting oxidative stress pathways.
Main Results:
- Oxidative stress is a key driver in the pathogenesis of CLD and liver fibrosis.
- Preclinical antioxidant interventions show promise but lack clinical efficacy in reducing fibrosis.
- Targeting specific enzymatic oxidant sources and ROS-mediated processes is a promising therapeutic avenue.
Conclusions:
- Effective treatments for CLD and liver fibrosis require novel strategies beyond general antioxidant supplementation.
- Selective modulation of redox homeostasis offers a more targeted approach to combat oxidative stress-induced liver injury.
- Further research into specific pharmacological interventions is crucial for developing effective CLD therapies.
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