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Overview of miR-106a Regulatory Roles: from Cancer to Aging

Maryam Daneshpour1, Ali Ghadimi-Daresajini2

  • 1Biotechnology Department, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.

Bioengineering (Basel, Switzerland)
|August 26, 2023
PubMed

Insights

MicroRNA-106a (miR-106a) shows promise as a diagnostic and therapeutic tool in various diseases, particularly cancers. Further research is needed to validate its clinical application.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are non-coding RNA molecules with crucial regulatory functions in cellular processes.
  • MiR-106a plays a significant role in regulating cell cycle and apoptosis, making it a focus for disease research.

Purpose of the Study:

  • To conduct a comprehensive review of miR-106a expression levels across various cancers and diseases.
  • To emphasize the target genes regulated by miR-106a and its implications.
  • To assess the potential of miR-106a as a diagnostic, prognostic, and therapeutic biomarker.

Main Methods:

  • Literature review of studies investigating miR-106a expression and its target genes.
  • Analysis of miR-106a's role in disease association, including cancer drug resistance.
  • Synthesis of findings on miR-106a's regulatory functions in different tissues.

Main Results:

  • miR-106a regulates critical cell cycle and apoptosis factors.
  • Expression levels of miR-106a are associated with various cancers and diseases.
  • miR-106a's role in cancer drug resistance highlights its complex functions.

Conclusions:

  • miR-106a demonstrates significant potential as a valuable diagnostic and prognostic biomarker.
  • Its therapeutic potential is evident, but requires further validation for clinical implementation.
  • Understanding miR-106a's target genes and regulatory networks is crucial for future applications.
Keywords:
biomarkercancerdrug resistancemiR-106amicroRNA

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