Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma oxytocin, early predictor of transient postoperative arginine vasopressin deficiency.

The Journal of clinical endocrinology and metabolism·2026
Same author

A Fully MRI-Compatible, Non-Electrical System for Near Real-Time Tremor Monitoring During MR-guided Focused Ultrasound.

Stereotactic and functional neurosurgery·2026
Same author

Established and emerging neuromodulation for drug-resistant epilepsy.

Clinical neurology and neurosurgery·2026
Same author

Frontal subcortical executive dysfunction and minor hallucinations in Parkinson's disease are linked to sensitivity to somatomotor conflicts.

Journal of Parkinson's disease·2026
Same author

AI-based detection of Certas Plus shunt valve settings in CT scans.

Scientific reports·2026
Same author

Surgical management of sellar arachnoid cyst: state of the art and systematic review.

Frontiers in neurology·2026

Related Experiment Video

Updated: Jul 18, 2025

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

10.8K

Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes.

Colette Boëx1,2, Abdullah Al Awadhi1, Rémi Tyrand1,2

  • 1Department of Neurosurgery, University Hospitals of Geneva, CH-1205 Geneva, Switzerland.

Bioengineering (Basel, Switzerland)
|August 26, 2023
PubMed
Summary

This study validates Lead-DBS software for mapping Parkinson's disease brain targets. It confirms that optimal deep brain stimulation (DBS) sites are often ventral to the sensorimotor subthalamic nucleus (STN).

Keywords:
Parkinson’s diseaselead-DBSlocal field potentialssubthalamic nucleus

More Related Videos

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.9K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.3K

Related Experiment Videos

Last Updated: Jul 18, 2025

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

10.8K
Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.9K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.3K

Area of Science:

  • Neuroscience
  • Neurosurgery
  • Biomedical Engineering

Background:

  • Deep brain stimulation (DBS) is a key treatment for Parkinson's disease.
  • Accurate targeting of the subthalamic nucleus (STN) is crucial for effective DBS.
  • The Lead-DBS toolbox aids in reconstructing stimulation locations but requires validation.

Purpose of the Study:

  • To compare probabilistic locations of beta-oscillations derived from Lead-DBS with intraoperative electrophysiological recordings.
  • To validate the accuracy of Lead-DBS in identifying optimal stimulation sites within the STN for Parkinson's disease patients.

Main Methods:

  • Utilized Vercise Cartesia directional electrodes and Lead-DBS software for electrode reconstruction.
  • Recorded intraoperative monopolar beta-oscillations from local field potentials (LFPs).
  • Compared spectral power densities of beta-band activity (13-31 Hz) across electrode contacts.
  • Applied DBS atlases (DISTAL, electrophysiological, DBS target) to preoperative MRI and postoperative CT scans.

Main Results:

  • Thirty-six electrodes from 20 Parkinson's disease patients were analyzed.
  • Optimal stimulation sites were frequently found dorsal and/or lateral to the sensorimotor STN.
  • In 33/36 electrodes, contacts showed stronger beta-oscillations, with 23 touching or within the probabilistic beta-oscillation volume.
  • Monopolar LFPs confirmed the ventral subpart of the probabilistic beta-oscillation volume.

Conclusions:

  • The Lead-DBS toolbox effectively reconstructs electrode locations and identifies optimal stimulation volumes for DBS in Parkinson's disease.
  • Intraoperative electrophysiology confirms that efficient stimulation sites are often located in the ventral aspect of the STN's probabilistic beta-oscillation volume.