Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes
Colette Boëx1,2, Abdullah Al Awadhi1, Rémi Tyrand1,2
1Department of Neurosurgery, University Hospitals of Geneva, CH-1205 Geneva, Switzerland.
Bioengineering (Basel, Switzerland)
|August 26, 2023
Summary
This study validates Lead-DBS software for mapping Parkinson's disease brain targets. It confirms that optimal deep brain stimulation (DBS) sites are often ventral to the sensorimotor subthalamic nucleus (STN).
Area of Science:
- Neuroscience
- Neurosurgery
- Biomedical Engineering
Background:
- Deep brain stimulation (DBS) is a key treatment for Parkinson's disease.
- Accurate targeting of the subthalamic nucleus (STN) is crucial for effective DBS.
- The Lead-DBS toolbox aids in reconstructing stimulation locations but requires validation.
Purpose of the Study:
- To compare probabilistic locations of beta-oscillations derived from Lead-DBS with intraoperative electrophysiological recordings.
- To validate the accuracy of Lead-DBS in identifying optimal stimulation sites within the STN for Parkinson's disease patients.
Main Methods:
- Utilized Vercise Cartesia directional electrodes and Lead-DBS software for electrode reconstruction.
- Recorded intraoperative monopolar beta-oscillations from local field potentials (LFPs).
- Compared spectral power densities of beta-band activity (13-31 Hz) across electrode contacts.
- Applied DBS atlases (DISTAL, electrophysiological, DBS target) to preoperative MRI and postoperative CT scans.
Main Results:
- Thirty-six electrodes from 20 Parkinson's disease patients were analyzed.
- Optimal stimulation sites were frequently found dorsal and/or lateral to the sensorimotor STN.
- In 33/36 electrodes, contacts showed stronger beta-oscillations, with 23 touching or within the probabilistic beta-oscillation volume.
- Monopolar LFPs confirmed the ventral subpart of the probabilistic beta-oscillation volume.
Conclusions:
- The Lead-DBS toolbox effectively reconstructs electrode locations and identifies optimal stimulation volumes for DBS in Parkinson's disease.
- Intraoperative electrophysiology confirms that efficient stimulation sites are often located in the ventral aspect of the STN's probabilistic beta-oscillation volume.
