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Updated: Jul 18, 2025
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
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Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders.
Joanna Kałafut1, Arkadiusz Czerwonka1, Karolina Czapla1
1Department of Biochemistry and Molecular Biology, Medical University of Lublin, Aleje Raławickie 1, 20-059 Lublin, Poland.
International Journal of Molecular Sciences
|August 26, 2023
Summary
Long non-coding RNAs (lncRNAs) modulate Notch1 signaling pathways, influencing their expression and activity. This review details lncRNAs
Area of Science:
- Molecular Biology
- Cell Signaling
- Genomics
Background:
- Notch1 signaling is crucial for tissue development and homeostasis.
- Dysregulation of NOTCH1 expression is linked to various health disorders.
- Notch1 signaling is regulated by transcriptional and post-translational mechanisms.
Purpose of the Study:
- To review the role of long non-coding RNAs (lncRNAs) in modulating Notch1 signaling.
- To explore the connection between lncRNAs, Notch1 signaling, and health disorders, particularly cancers.
Main Methods:
- Literature review of studies on lncRNAs and Notch1 signaling.
- Analysis of molecular mechanisms underlying lncRNA-mediated Notch1 regulation.
- Synthesis of data on the involvement of lncRNAs in disease pathogenesis.
Main Results:
- lncRNAs influence Notch1 signaling at multiple levels, including receptor activation and intracellular crosstalk.
- Specific lncRNAs are identified as key regulators of Notch1 pathway activity.
- Aberrant lncRNA expression is associated with the development and progression of cancers.
Conclusions:
- lncRNAs are significant modulators of Notch1 signaling.
- Targeting lncRNAs offers potential therapeutic strategies for Notch1-related disorders, especially cancer.
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