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Updated: Jul 18, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders

Joanna Kałafut1, Arkadiusz Czerwonka1, Karolina Czapla1

  • 1Department of Biochemistry and Molecular Biology, Medical University of Lublin, Aleje Raławickie 1, 20-059 Lublin, Poland.

International Journal of Molecular Sciences
|August 26, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) modulate Notch1 signaling pathways, influencing their expression and activity. This review details lncRNAs

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Genomics

Background:

  • Notch1 signaling is crucial for tissue development and homeostasis.
  • Dysregulation of NOTCH1 expression is linked to various health disorders.
  • Notch1 signaling is regulated by transcriptional and post-translational mechanisms.

Purpose of the Study:

  • To review the role of long non-coding RNAs (lncRNAs) in modulating Notch1 signaling.
  • To explore the connection between lncRNAs, Notch1 signaling, and health disorders, particularly cancers.

Main Methods:

  • Literature review of studies on lncRNAs and Notch1 signaling.
  • Analysis of molecular mechanisms underlying lncRNA-mediated Notch1 regulation.
  • Synthesis of data on the involvement of lncRNAs in disease pathogenesis.

Main Results:

  • lncRNAs influence Notch1 signaling at multiple levels, including receptor activation and intracellular crosstalk.
  • Specific lncRNAs are identified as key regulators of Notch1 pathway activity.
  • Aberrant lncRNA expression is associated with the development and progression of cancers.

Conclusions:

  • lncRNAs are significant modulators of Notch1 signaling.
  • Targeting lncRNAs offers potential therapeutic strategies for Notch1-related disorders, especially cancer.
Keywords:
NOTCHNotch signallingcancerlncRNAmicroRNA

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