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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Simultaneous Assessment of mTORC1, JAK/STAT, and NLRP3 Inflammasome Activation Pathways in Patients with Sarcoidosis

Raisa Kraaijvanger1, Carmen A Ambarus2, Jan Damen3

  • 1Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.

International Journal of Molecular Sciences
|August 26, 2023
PubMed

Insights

Investigating inflammatory pathways in sarcoidosis reveals that NLRP3 inflammasome activation is common and linked to chronic disease. These findings may enable personalized treatments targeting specific inflammatory pathways.

Area of Science:

  • Immunology
  • Pathology
  • Pharmacology

Background:

  • Sarcoidosis etiology is unknown, complicating treatment due to varied organ involvement and disease progression.
  • Cellular inflammatory pathways like mTORC1, JAK/STAT, and NLRP3 inflammasome are implicated in granuloma formation and are potential therapeutic targets.

Purpose of the Study:

  • To investigate the coexpression of mTORC1, JAK/STAT, and NLRP3 inflammasome pathways in sarcoidosis patients.
  • To determine if pathway coexpression correlates with disease outcomes.

Main Methods:

  • Immunohistochemistry was used to assess the activity of NLRP3, mTORC1, and JAK/STAT pathways in tissue samples from 60 sarcoidosis patients.
  • Correlation analysis was performed to link pathway activation with disease course.

Main Results:

  • NLRP3 inflammasome activation was observed in 85% of patients.
  • mTORC1 and JAK/STAT pathway activation were present in approximately 49% and 50% of patients, respectively.
  • NLRP3 activation at diagnosis was associated with a chronic sarcoidosis disease course.

Conclusions:

  • Distinct inflammatory tissue phenotypes in sarcoidosis were identified.
  • These findings may inform personalized medicine approaches using existing inhibitors for NLRP3, JAK-STAT, and mTORC1 pathways.
Keywords:
granulomaphenotypingsarcoidosissignaling pathways

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