Lessons from Animal Models in Sjögren's Syndrome

Area of Science:

• Rheumatology and Immunology
• Translational Medicine

Background:

• Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with diverse clinical manifestations.
• The exact pathogenesis of pSS remains incompletely understood, suggesting multifactorial origins.

Purpose of the Study:

• To review current research utilizing animal models that exhibit primary Sjögren's syndrome-like symptoms.
• To evaluate the contribution of these animal models to understanding pSS pathogenesis and treatment.

Main Methods:

• Comprehensive literature search of PubMed, Web of Science, Scopus, and Cochrane Library.
• Systematic review and synthesis of studies involving animal models of Sjögren's syndrome.

Main Results:

• Animal models have provided significant insights into the pathogenesis of Sjögren's syndrome.
• These models are instrumental in exploring potential therapeutic strategies and disease management.

Conclusions:

• Animal models are indispensable tools for advancing the understanding of primary Sjögren's syndrome.
• Further research using these models is essential for improving patient outcomes and developing effective treatments.