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A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
Published on: June 6, 2025
The ABC of Heart Transplantation-Part 1: Indication, Eligibility, Donor Selection, and Surgical Technique
Daniele Masarone1, Michelle M Kittleson2, Luigi Falco1
1Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy.
Insights
Cardiac transplantation is the best treatment for advanced heart failure when other therapies fail. This review covers patient selection, donor matching, and surgical techniques for heart transplants.
Area of Science:
- Cardiology
- Transplant Surgery
- Advanced Heart Failure Management
Background:
- Cardiac transplantation is the optimal treatment for end-stage heart failure unresponsive to medical or device therapy.
- Effective patient selection and timely referral are critical for successful cardiac transplant outcomes.
- Multidisciplinary evaluation is essential for determining transplant eligibility, even with relative contraindications.
Purpose of the Study:
- To outline the practical indications for cardiac transplantation.
- To detail the patient eligibility screening process for heart transplantation.
- To review donor selection principles and surgical techniques in cardiac transplantation.
Main Methods:
- Review of current literature and clinical guidelines on cardiac transplantation.
- Discussion of multidisciplinary team assessment protocols for transplant candidates.
- Analysis of donor matching criteria and surgical procedures.
Main Results:
- Successful cardiac transplantation requires careful patient selection and adherence to established protocols.
- Multidisciplinary evaluation ensures comprehensive assessment of transplant suitability.
- Donor selection and surgical technique are pivotal for post-transplant outcomes.
Conclusions:
- Cardiac transplantation offers a life-saving option for carefully selected advanced heart failure patients.
- The process involves rigorous patient evaluation, donor matching, and skilled surgical intervention.
- Optimizing selection and surgical procedures enhances the success of cardiac transplantation.
Abstract:
Cardiac transplantation represents the gold standard of treatment for selected patients with advanced heart failure who have poor functional capacity and prognosis despite guideline-directed medical therapy and device-based therapy. Proper patient selection and appropriate referral of patients to centers for the treatment of advanced heart failure are the first but decisive steps for screening patients eligible for cardiac transplantation. The eligibility and the decision to list for cardiac transplantation, even for patients with relative contraindications, are based on a multidisciplinary evaluation of a transplant team. This review will discuss the practical indications, the process of patient eligibility for cardiac transplantation, the principle of donor selection, as well as the surgical technique.
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