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Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility
Andrea Graziani1, Giuseppe Grande1, Michel Martin1
1Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, 35122 Padova, Italy.
Life (Basel, Switzerland)
|August 26, 2023
Summary
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects men under 50, potentially impacting male fertility. Understanding its links to infertility requires further research into accessory gland inflammation and other factors.
Area of Science:
- Urology
- Andrology
- Reproductive Medicine
Background:
- Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urologic condition in men under 50.
- CP/CPPS presents with pelvic pain, urinary symptoms, and/or sexual dysfunction lasting over 3 months.
- A significant association between CP/CPPS and male infertility has been observed.
Purpose of the Study:
- To explore the pathophysiological links between CP/CPPS and male infertility.
- To highlight the need for a multidisciplinary approach in managing CP/CPPS patients, especially those with infertility.
- To emphasize the importance of evaluating male accessory glands in infertile men.
Main Methods:
- Review of existing literature on CP/CPPS and male infertility.
- Analysis of proposed pathophysiological mechanisms connecting CP/CPPS to reduced semen parameters.
- Discussion of clinical implications for diagnosis and treatment.
Main Results:
- Reduced semen parameters are documented in men with CP/CPPS.
- Potential links include male accessory gland inflammation, metabolic syndrome, inflammatory bowel disease, HPV co-infection, and autoimmunity.
- These factors contribute to the complex relationship between CP/CPPS and infertility.
Conclusions:
- A comprehensive understanding of CP/CPPS requires considering its multifaceted impact on male reproductive health.
- A multidisciplinary approach is essential for effective management of CP/CPPS, particularly in infertile men.
- Future research should address the various pathophysiological aspects implicated in CP/CPPS and infertility.
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