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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Quercetin and Ferroptosis.

Alfredo Cruz-Gregorio1, Ana Karina Aranda-Rivera2

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Summary

Quercetin, a beneficial flavonoid, can induce cell death (ferroptosis) to treat cancer but inhibit it to protect against cardiovascular diseases. This review explores quercetin

Keywords:
cancerferroptosisinflammationliver injuryquercetinrenal injury

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Quercetin, a flavonoid found in various foods, exhibits cardioprotective, anti-inflammatory, and anticancer properties.
  • Oxidative stress from reactive oxygen species (ROS) damages cellular biomolecules, leading to conditions like ferroptosis, a distinct form of cell death.
  • Ferroptosis is implicated in diseases such as cancer (where its induction is beneficial) and cardiovascular diseases (where it is detrimental).

Purpose of the Study:

  • To review the dual role of quercetin in ferroptosis.
  • To explore quercetin's potential to induce ferroptosis for cancer treatment.
  • To examine quercetin's role in inhibiting ferroptosis for cardiovascular disease management.

Main Methods:

  • Literature review of studies investigating quercetin's effects on ferroptosis.
  • Analysis of mechanisms by which quercetin influences ferroptosis pathways.
  • Examination of quercetin's impact in both cancer and cardiovascular disease models.

Main Results:

  • Quercetin demonstrates the ability to induce ferroptosis, suggesting a potential therapeutic strategy for cancers.
  • Conversely, quercetin can deactivate ferroptosis, offering a protective mechanism against cardiovascular pathologies.
  • The specific mechanisms underlying quercetin's dual role in ferroptosis require further elucidation.

Conclusions:

  • Quercetin possesses a context-dependent role in ferroptosis, acting as an inducer in cancer and an inhibitor in cardiovascular diseases.
  • This review highlights quercetin as a promising therapeutic agent with versatile applications based on its ferroptosis-modulating capabilities.
  • Further research is warranted to fully understand and harness quercetin's ferroptosis-related effects for clinical benefit.