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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jun 20, 2026

In situ Transverse Rectus Abdominis Myocutaneous Flap: A Rat Model of Myocutaneous Ischemia Reperfusion Injury
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Multiple Flap Transfer for Multiple Local Recurrence of Soft Tissue Sarcoma.

Ryo Karakawa1, Hidehiko Yoshimatsu1, Yuma Fuse1

  • 1Department of Plastic and Reconstructive Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.

Medicina (Kaunas, Lithuania)
|August 26, 2023
PubMed
Summary

Multiple flap reconstructions are feasible for treating recurrent soft tissue sarcomas (STS). Surgeons should select flaps carefully, considering the high risk of recurrence and the need for future interventions.

Keywords:
flaplocal recurrencesarcoma

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Reconstructive Surgery

Background:

  • Surgical management of local recurrence of soft tissue sarcomas (STS) presents significant challenges.
  • Multiple local recurrences necessitate complex reconstructive strategies.

Purpose of the Study:

  • To report on the feasibility of multiple flap reconstructions for multiple local recurrences of STS.
  • To validate the efficacy of these procedures through clinical case examination.

Main Methods:

  • Retrospective study of patients undergoing multiple flap reconstructions for recurrent STS (April 1997 - October 2021).
  • Analysis of patient demographics, tumor characteristics, surgical details, and postoperative outcomes.
  • Inclusion of 8 patients with 20 operations, focusing on defect and flap sizes, histological diagnoses, and complication rates.

Main Results:

  • Twenty operations across 8 patients were analyzed, with defects located on the back, buttock, groin, and lower extremities.
  • Average wide resections were 4.0, and average flap reconstructions were 2.5 per patient.
  • Complication rates (take back, flap, donor-site) were higher in primary operations (25%, 25%, 12.5%) compared to subsequent operations (0%, 0%, 16.7%), with 50% of previous flaps requiring resection in later surgeries.

Conclusions:

  • Multiple wide resections and subsequent flap reconstructions are a feasible approach for managing multiple local recurrences of STS.
  • Reconstructive surgeons must consider the potential for future recurrence when selecting flap options for high-risk tumors.