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Updated: Jul 18, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Surmounting Cancer Drug Resistance: New Perspective on RNA-Binding Proteins

Yiyuan Feng1, Sha Zhu1, Tengwen Liu1

  • 1School of Basic Medical Sciences and State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Pharmaceuticals (Basel, Switzerland)
|August 26, 2023
PubMed

Insights

RNA-binding proteins (RBPs) regulate gene expression and RNA, influencing cancer. Targeting RBPs offers a promising strategy for overcoming cancer drug resistance and improving patient prognoses.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • RNA-binding proteins (RBPs) are crucial regulators of cellular processes, impacting RNA metabolism and gene expression.
  • Dysregulation of RBPs is implicated in cancer development by altering gene expression and post-transcriptional regulation.
  • Aberrant proteomes resulting from RBP dysfunction can disrupt the balance of oncogenes and tumor suppressor genes, driving cancer progression.

Purpose of the Study:

  • To explore the role of RBPs in cancer progression and drug resistance.
  • To highlight the potential of RBPs as therapeutic targets for overcoming cancer treatment challenges.
  • To emphasize the significance of RBPs as diagnostic and prognostic biomarkers in oncology.

Main Methods:

  • Review of existing literature on RNA-binding proteins in cancer.
  • Analysis of RBP involvement in gene expression and post-transcriptional regulation.
  • Investigation of molecular mechanisms linking RBPs to tumor drug resistance.

Main Results:

  • RBPs significantly influence cancer development and progression through modulation of gene expression.
  • Targeting RBPs presents a viable strategy to combat drug resistance in various cancer types.
  • RBPs demonstrate potential as reliable diagnostic and prognostic markers for cancer patients.

Conclusions:

  • Understanding RBP structure and function is key to developing novel cancer therapies.
  • Further research into RBP mechanisms in drug resistance can improve treatment efficacy and patient outcomes.
  • RBPs are critical players in cancer biology with significant implications for clinical oncology.
Keywords:
RNA-binding proteinscancerdrug resistancetherapy

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