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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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The Importance of Uncertainty Analysis and Traceable Measurements in Routine Quantitative ⁹⁰Y-PET Molecular

Marco D'Arienzo^1,2, Emilio Mezzenga³, Amedeo Capotosti⁴

¹Medical Physics Section, ASL Roma 6, Borgo Garibaldi 12, 00041 Rome, Italy.

Pharmaceuticals (Basel, Switzerland)

|August 26, 2023

Summary

This study evaluates uncertainty in ⁹⁰Y-PET quantification for Molecular Radiation Therapy (MRT). It proposes a framework to ensure accurate dose estimates and maintain acceptable treatment uncertainties in nuclear medicine.

Keywords:

90Y MRT PET dosimetry multicenter quantitative accuracy radionuclide therapy scanner uncertainty analysis

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Area of Science:

Nuclear Medicine
Medical Physics
Radiotherapy

Background:

Molecular Radiation Therapy (MRT) is crucial for treating malignancies like neuroendocrine tumors and liver cancers.
Accurate dose estimation and minimizing treatment uncertainties are vital in MRT practice.
Uncertainty propagation in ⁹⁰Y-PET quantification requires thorough evaluation.

Purpose of the Study:

To assess the quantitative accuracy of PET scanners under reference conditions.
To investigate uncertainty propagation in ⁹⁰Y-PET quantification.
To propose a framework for modeling quantification uncertainty based on GUM.

Main Methods:

Quantitative accuracy assessment of three PET scanners (Siemens Biograph mCT, Siemens Biograph mCT flow, GE Discovery DST).
Evaluation of uncertainty components in the quantification chain, including calibration.
Application of the Guide to the Expression of Uncertainty in Measurement (GUM) framework.

Main Results:

The study assessed PET scanner accuracy in Italian Nuclear Medicine centers.
Uncertainty in the calibration procedure was specifically addressed.
A GUM-based framework was proposed for uncertainty modeling in ⁹⁰Y-PET quantification.

Conclusions:

The proposed GUM-based framework aids in modeling uncertainty in ⁹⁰Y-PET quantification.
The study provides an estimation of achievable uncertainty in clinical settings.
Ensuring accurate dose estimates is critical for effective Molecular Radiation Therapy.