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Correction: Gottschalk et al. Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion. <i>Pharmaceutics</i> 2022, <i>14</i>, 1757.

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Material Transport Characteristics in Planetary Roller Melt Granulation.

Tom Lang1, Andreas Bramböck2, Markus Thommes1

  • 1Laboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, Germany.

Pharmaceutics
|August 26, 2023
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Planetary roller melt granulation (PRMG) offers dust reduction and eliminates drying steps. This study investigates material transport in PRMG, crucial for continuous pharmaceutical manufacturing and improved product quality.

Keywords:
continuous melt granulationplanetary roller granulatorresidence time distribution

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Melt granulation improves material handling and particle size distribution.
  • Continuous manufacturing in pharmaceuticals reduces quality fluctuations.
  • Planetary roller granulators offer advantages over twin-screw systems due to their design and process control.

Purpose of the Study:

  • To investigate the residence time distribution in planetary roller melt granulation (PRMG).
  • To understand material transport characteristics within the PRMG system.
  • To establish PRMG as a viable continuous manufacturing method in pharmaceutical technology.

Main Methods:

  • Utilizing a planetary roller granulator for melt granulation.
  • Investigating residence time distribution as an indicator of material transport.
  • Employing a two-compartment model to analyze axial transport and mixing.

Main Results:

  • Altering feed rate and rotation speed adjusts granulator fill level, affecting transport velocity and mixing.
  • The unique design of planetary roller granulators enhances the heated surface to processed volume ratio.
  • The two-compartment model effectively reflects the interplay between transport and mixing dynamics.

Conclusions:

  • PRMG is a promising continuous manufacturing technology for pharmaceutical applications.
  • Understanding residence time distribution is key to optimizing PRMG processes.
  • PRMG offers significant advantages in dust reduction and eliminating drying steps compared to conventional methods.