Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing Fab-Functionalized Gold Nanoparticles-Mediated Thermal Enhancement during High-Intensity Focused Ultrasound Ablation in a Mouse Tumor Model.

ACS applied bio materials·2025
Same author

Dual Role of Dendronized Gold Nanoparticles as Both Catalyst and Cargo-Loading Core in the Formation of Gold Nanorattles.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Oleic acid rearrangement enables facile transfer of red-emitting quantum dots from hexane into water with enhanced fluorescence.

Nanoscale·2025
Same author

A high-throughput lysosome trafficking assay guides ligand selection and elucidates differences in CD22-targeted nanodelivery.

Science and technology of advanced materials·2024
Same author

Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form.

Langmuir : the ACS journal of surfaces and colloids·2019
Same author

Dehydrative glycosylation with cyclic phosphonium anhydrides.

Organic & biomolecular chemistry·2016

Related Experiment Video

Updated: Jun 17, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.0K

Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles.

Lance T Dockery1, Marie-Christine Daniel1

  • 1Department of Chemistry and Biochemistry, University of Maryland Baltimore County (UMBC), Baltimore, MD 21250, USA.

Pharmaceutics
|August 26, 2023
PubMed
Summary

Multifunctional gold nanoparticles (AuNPs) were engineered for targeted prostate cancer therapy. These dendronized nanoparticles effectively delivered doxorubicin (DOX) and showed high efficacy in preclinical models.

Keywords:
dendronsdoxorubicingold nanoparticlesprostate cancertargeted delivery

More Related Videos

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
06:06

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

Published on: March 9, 2019

5.5K
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.0K

Related Experiment Videos

Last Updated: Jun 17, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.0K
Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
06:06

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

Published on: March 9, 2019

5.5K
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.0K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Oncology

Background:

  • Dendronized nanoparticles combine properties of nanoparticles and dendrimers for enhanced drug delivery.
  • Poly(propylene imine) (PPI) dendrons offer a proton sponge effect for improved intracellular drug release.
  • Prostate cancer remains a significant health concern, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To design and characterize multifunctional gold nanoparticles (AuNPs) for targeted prostate cancer therapy.
  • To incorporate doxorubicin (DOX) and an EphA2-targeting moiety onto AuNPs for combined chemo-targeting.
  • To evaluate the in vitro efficacy of these targeted nanoparticles.

Main Methods:

  • Synthesis of gold nanoparticles (AuNPs) coated with poly(propylene imine) (PPI) dendrons.
  • Attachment of doxorubicin (DOX) via an acid-sensitive hydrazone bond.
  • Conjugation of an EphA2-targeting antibody fragment using click chemistry.
  • In vitro cell viability assays using PC3 prostate cancer cells.

Main Results:

  • The AuNP system demonstrated pH-sensitive release of 140 DOX molecules per nanoparticle at pH 4-5.
  • Targeted AuNPs exhibited potent in vitro cytotoxicity against PC3 cells with an IC50 of 0.9 nM after 48 hours.
  • The system successfully combined drug delivery and active targeting for cancer cells.

Conclusions:

  • Multifunctional dendronized AuNPs show significant promise as a targeted drug delivery system for prostate cancer.
  • The proton sponge effect of PPI dendrons facilitates intracellular drug release.
  • Further optimization could lead to a novel therapeutic agent for prostate cancer treatment.