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Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer

Arif Budiman1, Annisa Luthfiyah Handini1, Mutia Nur Muslimah1

  • 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Bandung 45363, Indonesia.

Polymers
|August 26, 2023
PubMed

Insights

Amorphous solid dispersion (ASD) enhances oral anticancer drug bioavailability by improving solubility. This formulation strategy offers improved efficacy and safety for cancer therapy.

Area of Science:

  • Pharmaceutical Sciences
  • Oncology
  • Drug Delivery

Background:

  • Oral anticancer drug administration is limited by poor water solubility and bioavailability.
  • Suboptimal pharmacokinetics reduce efficacy and safety of oral cancer treatments.
  • Novel formulation strategies are crucial for enhancing oral drug performance.

Purpose of the Study:

  • To review and explain the mechanisms of amorphous solid dispersion (ASD) systems.
  • To elucidate the impact of ASD on cancer therapy.
  • To highlight the role of molecular pharmaceutics in ASD design for anticancer drugs.

Main Methods:

  • Comprehensive literature search using keywords 'anticancer drug' and 'amorphous solid dispersion'.
  • Databases searched include PubMed, Scopus, and Google Scholar.
  • Review and discussion of existing research on ASD for oral drug formulations.

Main Results:

  • Amorphous solid dispersion significantly enhances aqueous solubility and bioavailability of poorly water-soluble drugs.
  • Polymers in ASD formulations provide stability and maintain supersaturation.
  • ASD systems offer a promising approach to improve oral anticancer drug efficacy and safety.

Conclusions:

  • Amorphous solid dispersion is a key strategy for improving oral anticancer drug delivery.
  • Understanding the molecular interactions within ASD systems is vital for rational drug design.
  • Further research into ASD formulations can optimize cancer treatment outcomes.
Keywords:
amorphous solid dispersionbioavailabilitydissolutionpoorly water-soluble anticancer drugs

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