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Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts
Published on: February 5, 2018
Living-Neuron-Based Autogenerator
Svetlana A Gerasimova1, Anna Beltyukova1, Anastasia Fedulina1
1Department of Control Theory and System Dynamics, Neurotechnology Department, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia.
Abstract:
We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh-Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications.
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