Related Experiment Video

Updated: Jul 18, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.2K

Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis

Mykhailo Buchynskyi1, Valentyn Oksenych2, Iryna Kamyshna3

  • 1Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.

Viruses
|August 26, 2023
PubMed

Insights

Genetic factors influence metabolic-associated fatty liver disease (MAFLD) and COVID-19 severity. Specific gene variants linked to MAFLD show mixed associations with severe COVID-19 outcomes, requiring further research.

Area of Science:

  • Genetics
  • Hepatology
  • Infectious Diseases

Background:

  • Metabolic-associated fatty liver disease (MAFLD), formerly NAFLD, and its link to COVID-19 severity are significant research areas.
  • Genetic polymorphisms are known to influence MAFLD susceptibility and progression.

Purpose of the Study:

  • To review genetic determinants of MAFLD and their potential impact on COVID-19 outcomes.
  • To explore specific gene variants (PNPLA3, GCKR, TM6SF2, LYPLAL1) associated with MAFLD.

Main Methods:

  • Literature review of genome-wide association studies and meta-analyses.
  • Examination of studies investigating genetic variants in MAFLD and COVID-19.

Main Results:

  • Several genetic polymorphisms (PNPLA3, GCKR, TM6SF2, LYPLAL1) are associated with MAFLD risk and metabolic dysfunction.
  • The association between these MAFLD-related genetic variants and COVID-19 severity is currently inconclusive, with conflicting findings.

Conclusions:

  • Understanding MAFLD genetic determinants is crucial for assessing COVID-19 outcomes.
  • Further research is needed to clarify the role of these genetic variants in disease severity and for potential risk stratification in COVID-19 patients.
Keywords:
COVID-19GCKRLYPLAL1MAFLDNAFLDPNPLASARS-CoV-2TM6SF2rs12137855rs58542926rs738409rs780094

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.3K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.2K
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
611
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
337
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.3K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.6K
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.4K