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Relationships Between Inflammatory Parameters Derived From Complete Blood Count and Quantitative Flow Ratio in
Yanqing Xie1,2, Han Cen2,3, Li Wang1
1Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Insights
Inflammatory markers like monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) are linked to reduced coronary flow in stable coronary artery disease (CAD) patients. These findings highlight potential biomarkers for assessing disease severity.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biomarkers
Background:
- Stable coronary artery disease (CAD) management relies on assessing coronary physiology.
- Inflammatory markers are increasingly recognized as contributors to cardiovascular disease pathogenesis.
Purpose of the Study:
- To investigate the association between key inflammatory parameters and quantitative flow ratio (QFR) in stable CAD patients.
- To determine if neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII) correlate with impaired coronary flow.
Main Methods:
- Cross-sectional study of 450 stable CAD patients.
- Logistic regression analysis to assess associations between inflammatory markers (NLR, PLR, MLR, SII) and QFR ≤0.80.
- Inflammatory markers evaluated as both continuous and binary variables.
Main Results:
- Monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) were significantly associated with a QFR ≤0.80, indicating reduced coronary flow.
- Neutrophil-to-lymphocyte ratio (NLR) showed borderline significance.
- Platelet-to-lymphocyte ratio (PLR) was not significantly associated with QFR.
Conclusions:
- MLR and SII are significant indicators of impaired coronary physiology in stable CAD.
- These inflammatory indices may serve as valuable biomarkers for evaluating coronary artery disease severity.
Abstract:
To investigate the relationships between inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII), and quantitative flow ratio (QFR) in stable coronary artery disease (CAD) patients (n = 450) enrolled in this cross-sectional study. Logistic regression was performed to evaluate the associations of NLR, PLR, MLR, and SII evaluated as continuous and binary variables with QFR ≤0.80. When treated as continuous variables, lnNLR was associated with QFR ≤0.80 with borderline significance in univariable (odds ratio (OR) = 1.60, p = .05) and multivariable analysis (OR = 1.72, p = .05), while lnMLR was associated with QFR ≤0.80 significantly in univariable analysis (OR = 1.87, p = .03) and with borderline significance in multivariable analysis (OR = 1.91, p = .05). When treated as binary variables, high levels of MLR and SII were significantly associated with QFR ≤0.80 in univariable (MLR: OR = 1.91, p = .02; SII: OR = 2.42, p = .006) and multivariable analysis (MLR: OR = 1.83, p = .04; SII: OR = 2.19, p = .02). NLR, MLR, and SII, but not PLR, were significantly associated with the severity of coronary physiology in stable CAD patients.
