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Inflammation associated with left ventricular hypertrophy in bipolar disorder: A cross-sectional study
Shang-Ying Tsai1, Pao-Huan Chen1, Cheng-Yi Hsiao2
1Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
Journal of Psychosomatic Research
|August 26, 2023
Summary
Bipolar disorder (BD) patients show increased cardiac abnormalities like left ventricular hypertrophy (LVH) and hyperdynamic heart. Low-grade inflammation, specifically interleukin-8 and sTNF-R1, is linked to these cardiac changes in BD.
Area of Science:
- Cardiology
- Psychiatry
- Immunology
Background:
- Inflammation is increasingly recognized in the pathophysiology of bipolar disorder (BD) and cardiac hypertrophy leading to heart failure.
- Investigating BD-related inflammatory markers offers insight into cardiac function and structure in BD patients.
Purpose of the Study:
- To examine the relationship between BD-related inflammatory markers and cardiac left ventricular function and structure.
- To assess cardiac parameters in euthymic BD patients compared to healthy controls.
Main Methods:
- Echocardiography was used to measure left ventricular mass index (LVMI) for hypertrophy and left ventricle ejection fraction (LVEF) for systolic function.
- A hyperdynamic heart was defined as LVEF >70%.
- Inflammatory and atherosclerosis-related markers were measured in 60 BD patients and 50 healthy controls.
Main Results:
- BD patients exhibited higher rates of LVH (63% vs. 42%) and hyperdynamic heart (32% vs. 2%) compared to controls.
- BD patients had significantly higher mean LVMI and LVEF values.
- Interleukin-8 correlated positively with LVMI, and sTNF-R1 correlated positively with LVEF in BD patients after adjusting for BMI and age.
Conclusions:
- Young adult BD patients often present with LVH and a hyperdynamic heart, potentially indicating diastolic dysfunction.
- Low-grade inflammation may be a key mechanism driving left ventricular hypertrophy and cardiac dysfunction in bipolar disorder.
Keywords:
Bipolar disorderEchocardiographyHeart failureInflammationInterleukin-8 (IL-8)Left ventricular hypertrophysTNF-R1More Related Videos
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