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Structural analysis of polysaccharide/antisense DNA complexes during cytoplasmic target mRNA hybridization

Kazuki Sumiya1, Hiroto Izumi2, Kazuo Sakurai1

  • 1Department of Chemistry and Biochemistry, University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0135, Japan.

Bioorganic & Medicinal Chemistry Letters
|August 26, 2023
PubMed
Summary

Antisense oligonucleotides (AS-ODNs) complexed with poly(dA) and schizophyllan efficiently deliver AS-ODNs into cells. The complex maintains its structure during cytoplasmic translocation and enables AS-ODN hybridization with target mRNA.

Keywords:
Antisense oligonucleotidesDectin-1Endosome escapeSchizophyllan

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