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Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups

Hui-Min Mao1, Shun-Gen Huang2, Yang Yang1

  • 1Department of Radiology, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, China.

BMC Pediatrics
|August 26, 2023
PubMed

Insights

Pancreaticobiliary maljunction (PBM) presents differently in children across age groups. Jaundice is common in infants, while older children experience abdominal pain and vomiting, indicating a need for age-specific PBM management.

Area of Science:

  • Pediatric Gastroenterology
  • Congenital Malformations
  • Hepatobiliary Diseases

Background:

  • Pancreaticobiliary maljunction (PBM) is a congenital defect associated with pancreaticobiliary and hepatic complications.
  • Clinical presentations of PBM are thought to differ between children and adults.
  • Limited studies exist on PBM in distinct pediatric age groups.

Purpose of the Study:

  • To evaluate clinicopathological characteristics and outcomes of PBM in pediatric patients.
  • To analyze age-related differences in PBM presentation and complications.

Main Methods:

  • Retrospective review of 166 pediatric PBM patients.
  • Data collected: clinicopathological, imaging, laboratory, surgical, and follow-up.
  • Patients categorized into three age groups: <1 year (Group A), 1-3 years (Group B), and >3 years (Group C).

Main Results:

  • Jaundice was the primary symptom in Group A; abdominal pain and vomiting in Groups B and C.
  • Acute pancreatitis was more frequent in Group C.
  • Group C had a longer common channel and smaller common bile duct diameter than Group A.
  • Cholangitis and cholecystitis were more common in Groups B and C; hepatic fibrosis in Group A.
  • Elevated serum amylase was more common in Group C, while abnormal liver function tests were seen in Groups A and B.

Conclusions:

  • PBM presentation varies significantly across different pediatric age groups.
  • Age-specific clinical characteristics suggest the need for tailored management strategies for PBM in children.
Abstract

Keywords:
AgeChildrenClinical presentationOutcomesPancreaticobiliary maljunction

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