Related Experiment Video
Updated: Jul 18, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Bullous Pemphigoid Developed after the COVID-19 Vaccine
Rubén Linares-Navarro1, Gorka Ruiz-Carrillo Ramírez2, Héctor Perandones-González2
1Department of Dermatology, University Hospital of Leon, León, Spain; rlinares@saludcastillayleon.es.
Abstract:
A 91-year-old man presented with pruriginous tense blisters and erosions on the upper and lower extremities (Figures 1A and 1B). Mucous membranes were unaffected and Nikolsky's sign was negative. These lesions appeared 48 hours after the administration of the second dose of the Pfizer-BioNTech COVID-19 vaccine. The patient had received the first dose of the same vaccine 23 days prior to the onset of lesions. He did not suffer from any other post-vaccination adverse effects.
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