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Critical limb-threatening ischaemia and microvascular transformation: clinical implications

Santeri Tarvainen1,2, Galina Wirth1,2, Greta Juusola1,2

  • 1Heart Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.

European Heart Journal
|August 27, 2023
PubMed
Summary

Critical limb-threatening ischaemia (CLTI) involves microvascular changes like capillary enlargement, worsening muscle function and tissue damage. These hypoxia-driven transformations are key to CLTI progression and treatment strategies.

Keywords:
AngiogenesisCapillariesChronic limb-threatening ischaemiaGrowth factorHypoxiaIschaemiaMicrovascular remodellingPeripheral arterial diseaseVascular endothelial

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