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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
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New-onset atrial fibrillation and chronic coronary syndrome in the CLARIFY registry
Alexandre Gautier1,2, Fabien Picard2,3, Gregory Ducrocq1,2
1Department of Cardiology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, French Alliance for Cardiovascular Trials, INSERM U1148, Laboratory for Vascular Translational Science, 46 rue Henri Huchard, 75018 Paris, France.
European Heart Journal
|August 27, 2023
Summary
New-onset atrial fibrillation (NOAF) is common in chronic coronary syndromes (CCS) patients and significantly increases cardiovascular risks. Early detection and intervention strategies for NOAF in CCS are crucial for improving patient prognosis.
Area of Science:
- Cardiology
- Epidemiology
- Clinical Research
Background:
- Limited data exist on new-onset atrial fibrillation (NOAF) in patients with chronic coronary syndromes (CCS).
- Understanding NOAF incidence, predictors, and outcomes in CCS is vital for patient management.
Purpose of the Study:
- To determine the incidence, identify predictors, and assess the impact of NOAF on cardiovascular outcomes in CCS patients.
- To analyze data from the international CLARIFY registry for insights into NOAF in stable coronary artery disease.
Main Methods:
- Utilized data from 29,001 CCS outpatients in the CLARIFY registry across 45 countries.
- Compared patients who developed NOAF during 5-year follow-up with those remaining in sinus rhythm.
- Employed statistical analysis to identify independent predictors and assess outcome risks.
Main Results:
- The incidence rate of NOAF was 1.12 per 100 patient-years (5.0% cumulative incidence at 5 years).
- Independent predictors included older age, higher BMI, lower eGFR, Caucasian ethnicity, alcohol intake, and reduced LVEF.
- NOAF significantly increased risks for CV death, MI, stroke, all-cause death, heart failure hospitalization, and major bleeding.
Conclusions:
- NOAF is prevalent in CCS patients and strongly linked to adverse cardiovascular outcomes.
- Further research is warranted on intensive preventive measures and systematic AF screening to improve prognosis in this population.
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