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Related Experiment Video

Updated: Jul 18, 2025

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Published on: January 12, 2011

Examining post-concussion white matter change in a pediatric sample.

Michael Takagi¹, Gareth Ball², Franz E Babl³

¹Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Melbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia; Department of Rehabilitation Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia; Monash School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.

Neuroimage. Clinical

|August 27, 2023

Summary

Diffusion-Weight Imaging (DWI) did not reveal significant white matter differences in children with concussion, suggesting current methods may not detect subtle neurobiological changes impacting recovery.

Keywords:

Diffusion weighted imaging Mild traumatic brain injury Pediatric concussion Pediatric neuroimaging Persisting post-concussion symptoms Post-concussion syndrome

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Last Updated: Jul 18, 2025

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Published on: January 12, 2011

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A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

Published on: December 8, 2014

Area of Science:

Neuroimaging
Pediatric Neurology
Biomedical Engineering

Background:

Diffusion-Weight Imaging (DWI) is crucial for pediatric concussion research, but findings are inconsistent due to methodological variations.
Understanding the neurobiological basis of symptom recovery in pediatric concussion is essential.

Purpose of the Study:

To conduct a comprehensive, multi-parametric survey of white matter microstructure in pediatric concussion using standardized criteria and imaging timepoints.
To investigate if white matter microstructure changes detected by DWI correlate with delayed recovery from concussion.

Main Methods:

Utilized Linked Independent Component Analysis (LICA) to combine multiple DWI metrics from four modeling approaches.
Analyzed neuroimaging data from 43 children with concussion, categorized by recovery status at 2 weeks post-injury.
Applied internationally recognized concussion criteria and a consistent imaging timepoint.

Main Results:

No significant differences in white matter microstructure patterns were found between symptomatic and asymptomatic children.
No identified components from the DWI analysis significantly predicted delayed concussion recovery.
The study cohort included 27 normally recovering and 14 delayed recovering children.

Conclusions:

Current diffusion imaging techniques may be insufficient to detect white matter microstructural changes associated with delayed recovery in pediatric concussion.
Further research is needed to refine imaging methods for better understanding concussion neurobiology and recovery.
The heterogeneity in DWI findings in pediatric concussion literature highlights the need for standardized methodologies.