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Updated: Jul 18, 2025

Techniques to Induce and Quantify Cellular Senescence
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USP13 regulates cell senescence through mediating MDM2 stability

Jinshan He1, Boina Baoyinna2, Sarah J Taleb2

  • 1Department of Physiology and Cell Biology, the Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, the Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Life Sciences
|August 27, 2023
PubMed
Summary

Ubiquitin-Specific Protease 13 (USP13) promotes lung cell senescence and aging by reducing MDM2 levels. This deubiquitinating enzyme plays a key role in lung aging mechanisms.

Keywords:
Cell senescenceDeubiquitinationLung agingMDM2USP13

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