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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release.

Manoj B Sharma1,2, Özlem Kap3, Hend A M Abdelmohsen1,4

  • 1Department of Chemistry Lancaster University Lancaster LA1 4YB UK.

Global Challenges (Hoboken, NJ)
|August 28, 2023
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Summary

This study demonstrates in vitro metformin release from poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel microneedles. These microneedles show potential for transdermal delivery in treating cancer, diabetes, and aging.

Keywords:
agingcancerdiabetesdrug deliveryhydrogelsmicroneedles

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Metformin is a key drug for diabetes and cancer treatment.
  • Transdermal drug delivery offers advantages over traditional methods.
  • Hydrogel-based microneedles present a novel approach for controlled drug release.

Purpose of the Study:

  • To demonstrate in vitro release of metformin from pHEMA hydrogel microneedle patches.
  • To investigate the effect of hydrogel composition on microneedle properties and drug release kinetics.
  • To evaluate the potential of pHEMA microneedles for transdermal metformin delivery.

Main Methods:

  • Fabrication of poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel microneedle patches.
  • Mechanical property testing to ensure skin penetrability (insertion force ≈40 N).
  • In vitro swelling and drug release studies at varying temperatures (20, 35, 60 °C) and kinetic modeling.

Main Results:

  • Robust pHEMA microneedle patches were successfully prepared with appropriate mechanical strength for skin insertion.
  • Swelling behavior and drug diffusion kinetics exhibited temperature dependence.
  • Metformin release profiles were analyzed using zero-order, first-order, and second-order models.

Conclusions:

  • pHEMA hydrogel microneedles are a viable platform for transdermal metformin delivery.
  • The tunable properties of pHEMA hydrogels allow for controlled drug release.
  • These microneedles hold promise for treating conditions like diabetes, cancer, and aging via transdermal administration.