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Computerized Games versus Crosswords Training in Mild Cognitive Impairment.

D P Devanand1,2, Terry E Goldberg1,2,3, Min Qian4

  • 1Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York.

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|August 28, 2023
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Summary
This summary is machine-generated.

Web-based crossword puzzles improved cognitive function in individuals with mild cognitive impairment (MCI) over 78 weeks, outperforming cognitive games. This study highlights the potential of targeted digital interventions for cognitive health.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Mild cognitive impairment (MCI) is a significant risk factor for dementia.
  • The effectiveness of cognitive training interventions for individuals with MCI remains uncertain.
  • Understanding effective strategies to support cognitive health in aging populations is crucial.

Purpose of the Study:

  • To evaluate the efficacy of home-based, computerized cognitive training in individuals diagnosed with mild cognitive impairment.
  • To compare the effects of web-based cognitive games versus web-based crossword puzzles on cognitive and functional outcomes.
  • To assess the impact of cognitive training on brain structure, including hippocampal volume and cortical thickness.

Main Methods:

  • A 78-week, two-site, single-blinded randomized trial involving 107 participants with MCI.
  • Participants were stratified by age, MCI severity, and study site.
  • Interventions included 12 weeks of intensive, home-based computerized training (cognitive games or crossword puzzles) with booster sessions.

Main Results:

  • Web-based crossword puzzles showed a statistically significant improvement in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) score compared to cognitive games at 78 weeks (P=0.04).
  • The crossword group experienced a mean improvement in ADAS-Cog scores, while the games group showed a slight worsening.
  • Greater decreases in hippocampal volume and cortical thickness were observed in the cognitive games group compared to the crossword group.

Conclusions:

  • Home-based computerized crossword puzzle training demonstrated superior efficacy over cognitive games in improving cognitive function among individuals with MCI over a 78-week period.
  • The findings suggest that specific types of digital cognitive interventions may be more beneficial for maintaining or improving cognitive status in MCI.
  • Further research into the long-term effects and mechanisms of different digital cognitive training modalities is warranted.