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Aging and primate male sexual behavior.

C H Phoenix, K C Chambers

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |November 1, 1986
    PubMed
    Summary

    Aging male rhesus macaques show reduced sexual behavior, independent of hormone levels. Sexual activity in old males can be restored with testosterone, particularly when paired with preferred females.

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    In memoriam: Robert W. Goy.

    Archives of sexual behavior·2000

    Area of Science:

    • Gerontology
    • Reproductive Endocrinology
    • Primate Behavior

    Background:

    • Aging male rhesus macaques exhibit decreased sexual behavior compared to younger counterparts.
    • This decline is not consistently linked to significant changes in gonadal hormones like testosterone (T), dihydrotestosterone (DHT), or luteinizing hormone (LH).
    • Physical disabilities associated with aging can impair sexual performance, but do not fully explain the general reduction in sexual activity.

    Purpose of the Study:

    • To investigate the factors contributing to the decline in sexual behavior in aging male rhesus macaques.
    • To determine the efficacy of testosterone administration in restoring sexual activity in older males.
    • To explore the role of environmental and social factors, such as partner novelty and preference, on sexual performance.

    Main Methods:

    • Comparison of sexual behavior across different age groups (young, middle-aged, old) of male rhesus macaques.
    • Hormonal assays to measure serum levels of T, DHT, and LH in diurnal patterns.
    • Administration of testosterone to old intact and long-term-castrated males.
    • Assessment of sexual performance with changes in female partners and environment.
    • Evaluation of the effects of specific drugs and rhinoceros horn on sexual behavior.

    Main Results:

    • Testosterone administration did not increase sexual activity in old intact males but was effective in old long-term-castrated males, restoring performance to levels of old intact males.
    • Neither changing the female partner nor the environment significantly improved sexual performance in old males.
    • Sexual behavior in old males increased to levels seen in young males only when they were paired with empirically selected preferred females.
    • Drugs effective in rats showed limited efficacy in old rhesus males, while powdered rhinoceros horn was more effective in humans.

    Conclusions:

    • The decline in sexual behavior in aging male rhesus macaques is not solely due to hormonal changes or physical disabilities.
    • Testosterone replacement therapy can restore sexual function in castrated older males, suggesting a potential role for hormone therapy.
    • Partner preference plays a crucial role in modulating sexual activity in aging males.
    • Rhesus macaques, due to their response patterns and lack of placebo effect, serve as a valuable model for studying sexual behavior in aging men.

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