Related Experiment Video

Updated: Jul 18, 2025

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

111.9K

Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression

Mina Alimohammadi1, Yasaman Gholinezhad2, Vahide Mousavi3

  • 1Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

EXCLI Journal
|August 28, 2023
PubMed

Insights

Circular RNAs (CircRNAs) are key regulators in lung cancer development by disrupting the Wnt/β-catenin pathway. Targeting these interactions offers new diagnostic and therapeutic strategies for lung cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Circular RNAs (CircRNAs) are regulatory RNA transcripts found in eukaryotes.
  • Dysregulation of CircRNAs impacts the Wnt/β-catenin pathway, crucial for biological processes including tumorigenesis.
  • Aberrant Wnt/β-catenin signaling is implicated in cancer development and progression.

Purpose of the Study:

  • To review current evidence on the role of CircRNAs in the Wnt/β-catenin pathway in lung cancer.
  • To highlight CircRNAs as potential diagnostic biomarkers and therapeutic targets for lung cancer.
  • To explore the advancement of CircRNA-based therapeutic strategies for lung cancer.

Main Methods:

  • Literature review of studies investigating CircRNAs and the Wnt/β-catenin pathway in lung cancer.
  • Analysis of current evidence on the regulatory mechanisms involved.
  • Synthesis of findings to outline diagnostic and therapeutic potential.

Main Results:

  • CircRNAs play significant roles in regulating lung cancer formation and development through Wnt/β-catenin pathway interactions.
  • Tumor-derived CircRNAs interacting with this pathway show potential as clinical diagnostic biomarkers.
  • These interactions also present promising therapeutic targets for lung cancer interventions.

Conclusions:

  • CircRNAs are critical in modulating lung cancer progression via the Wnt/β-catenin pathway.
  • Targeting CircRNA-Wnt/β-catenin interactions may lead to novel lung cancer diagnostics.
  • Further research into CircRNA-based therapies could revolutionize lung cancer treatment.
Keywords:
CircRNAWntlung cancermechanismsignaling cascades

More Related Videos

Identification of Circular RNAs using RNA Sequencing08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.3K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.4K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K