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Updated: Jul 18, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Acetamido-TEMPO mediated electrochemical oxidation of alcohols to aldehydes and ketones
Chelsea M Schroeder1, Fabrizio Politano1,2, Kristiane K Ohlhorst1
1Department of Chemistry, University of Connecticut 55 North Eagleville Road, Storrs Connecticut 06269 USA nicholas.leadbeater@uconn.edu.
Abstract:
A protocol for the oxidation of alcohols to aldehydes and ketones employing an electrochemical aminoxyl-mediated reaction is presented. The approach employs a catalytic amount of the radical and the use of a base is not required. It is performed using readily available electrodes in a commercially available electrochemistry apparatus and does not require a reference electrode. The methodology is applicable to a range of structurally and electronically diverse substrates, including the oxidation of primary alcohols to aldehydes rather than the more commonly formed carboxylic acids.
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