Related Experiment Video
Updated: Jul 18, 2025
Efficient and Consistent Generation of Retinal Pigment Epithelium/Choroid Flatmounts from Human Eyes for Histological Analysis
Published on: October 28, 2022
Pathophysiology and clinical aspects of epiretinal membrane - review
Mateusz Kamil Ożóg1,2, Marta Nowak-Wąs1,3, Wojciech Rokicki3,4
1Department of Histology and Cell Pathology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Abstract:
The epiretinal membrane (ERM) is a pathological tissue formed at the vitreoretinal interface. The formation of this tissue is associated with numerous symptoms related to disturbances of vision. These types of lesions may arise idiopathically or be secondary to eye diseases, injuries and retinal surgeries. ERM tissue contains numerous cell types and numerous cytokines, which participate in its formation. The aim of this paper is to summarize information about the etiology, epidemiology, pathophysiology and treatment of ERM, with a brief description of the main cells that build the ERM - as well as the cytokines and molecules related to ERM pathogenesis - being provided in addition.
Insights
Epiretinal membrane (ERM) is a vision-disturbing tissue forming at the eye's vitreoretinal interface. This review summarizes ERM
Area of Science:
- Ophthalmology
- Retinal Diseases
- Cell Biology
Background:
- Epiretinal membrane (ERM) is a pathological tissue at the vitreoretinal interface.
- ERM formation causes vision disturbances and can be idiopathic or secondary to ocular conditions.
- ERM composition includes diverse cell types and cytokines involved in its pathogenesis.
Purpose of the Study:
- To provide a comprehensive summary of epiretinal membrane (ERM).
- To detail the etiology, epidemiology, pathophysiology, and treatment of ERM.
- To describe key cells, cytokines, and molecules implicated in ERM formation.
Main Methods:
- Literature review and synthesis of existing research on epiretinal membranes.
- Analysis of cellular and molecular components contributing to ERM pathogenesis.
- Compilation of information on clinical presentation and management strategies.
Main Results:
- Epiretinal membranes arise from various cellular and molecular processes.
- Idiopathic and secondary causes contribute to ERM development.
- Specific cells and cytokines play crucial roles in ERM pathogenesis.
Conclusions:
- Epiretinal membranes are complex pathological entities affecting vision.
- Understanding ERM etiology, pathophysiology, and cellular components is vital for effective treatment.
- Further research into ERM pathogenesis may lead to improved therapeutic interventions.
More Related Videos
10:00Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
Published on: February 14, 2015
08:28Experimental Models for Study of Retinal Pigment Epithelial Physiology and Pathophysiology
Published on: November 6, 2010