A Study on Myloblastosis Gene (MYB) in Adenoid Cystic Carcinoma Using the New IHC Marker MYB (SZ04-81)

Background and aim: Adenoid cystic carcinoma is one of the most common malignant neoplasms of the salivary gland. It has overlapping histological features with other salivary gland tumors. MYB is a nuclear marker which is known to be expressed in Adenoid cystic carcinoma. In this study we aim to determine the sensitivity and specificity of MYB IHC marker to differentiate Adenoid cystic carcinoma from other benign and malignant salivary gland tumors. Materials and method: This is a retrospective case control study on the paraffin blocks of 78 cases of salivary gland tumors obtained over a period of 5 years. MYB Ser11 monoclonal antibody of clone SZ04-81 IHC, a nuclear marker was done on all cases. The results observed was tabulated and statistical analysis was done to calculate the sensitivity and specificity of the MYB IHC marker. Results: The mean age group of Adenoid cystic carcinoma was 45 years with a female preponderance. 60% of the cases of Adenoid cystic carcinoma were from minor salivary glands spread across various sites. The sensitivity and specificity of the MYB IHC marker were statistically analyzed and found to be 93.9% and 97.8% respectively. Conclusion: The present study shows substantial expression of MYB immunohistochemical marker in Adenoid cystic carcinoma, with a very high sensitivity and specificity obtained using the clone SZ04-81. Thus this marker can be used in the diagnosis of adenoid cystic carcinoma. However, correlation with H & E and FISH studies are required.

The online version contains supplementary material available at 10.1007/s12070-023-03471-4.